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Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis

Country : Malaysia
Department : Universiti Sains Malaysia, Malaysia
Project Title : Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis
Researcher : Parumasivam, Thaigarajan
Keyword : RS1-441 Pharmacy and materia medica
Year End : 2012
Identifier : http://eprints.usm.my/42806/1/THAIGARAJAN_PARUMASIVAM.pdf , Parumasivam, Thaigarajan (2012) Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis. PhD thesis, Universiti Sains Malaysia.
Relation : http://ezproxy.usm.my/login?url=http ://ethesis.usm.my/jspui , http://eprints.usm.my/42806/
Abstract / Description :

The low permeability of the cell envelope against hydrophilic anti-tuberculosis (TB) drugs especially isoniazid (INH), is one of the crucial factors that contribute to the intrinsic resistance in Mycobacterium tuberculosis. Previous studies have floated the idea that the anti-mycobacterial activity of INH can be enhanced by augmenting the hydrophilic INH into a hydrophobic/lipophilic compound. Therefore, a series of 13 derivatives with different hydrophobicity were synthesized by adding different hydrophobic acyl chain to the parent compound, INH.

References

Parumasivam, Thaigarajan . (2012). Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis.  Malaysia: Universiti Sains Malaysia, Malaysia.
Parumasivam, Thaigarajan . 2012. "Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis".  Malaysia: Universiti Sains Malaysia, Malaysia.
Parumasivam, Thaigarajan . "Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis."  Malaysia: Universiti Sains Malaysia, Malaysia, 2012. Print.
Parumasivam, Thaigarajan . Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis. Malaysia: Universiti Sains Malaysia, Malaysia; 2012.

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