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|Department||:||Universiti Sains Malaysia, Malaysia|
|Project Title||:||Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis|
|Keyword||:||RS1-441 Pharmacy and materia medica|
|Identifier||:||http://eprints.usm.my/42806/1/THAIGARAJAN_PARUMASIVAM.pdf , Parumasivam, Thaigarajan (2012) Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis. PhD thesis, Universiti Sains Malaysia.|
|Abstract / Description||:||
The low permeability of the cell envelope against hydrophilic anti-tuberculosis (TB) drugs especially isoniazid (INH), is one of the crucial factors that contribute to the intrinsic resistance in Mycobacterium tuberculosis. Previous studies have floated the idea that the anti-mycobacterial activity of INH can be enhanced by augmenting the hydrophilic INH into a hydrophobic/lipophilic compound. Therefore, a series of 13 derivatives with different hydrophobicity were synthesized by adding different hydrophobic acyl chain to the parent compound, INH.